Improved generation of anti-tumor immunity by antigen dose limitation |
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| Authors: | Joshua D Shofner Juan G Vasquez Carole L Berger Richard L Edelson |
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| Affiliation: | (1) Department of Dermatology, Yale University, 333 Cedar Street, New Haven, CT, USA;(2) Yale Comprehensive Cancer Center, Yale University, 333 Cedar Street, New Haven, CT, USA |
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| Abstract: | Background The malignant cells of cutaneous T cell lymphoma (CTCL) display immunogenic peptides derived from the clonal T cell receptor (TCR) providing an attractive model for refinement of anti-tumor immunization methodology. To produce a clinically meaningful anti-tumor response, induction of cytotoxic anti-CTCL cells must be maximized while suppressive T regulatory cells (Treg) should be minimized. We have demonstrated that engulfment of apoptotic CTCL cells by dendritic cells (DC) can lead to either CD8 anti-CTCL responses or immunosuppressive Treg induction. Treg generation is favored when the number of apoptotic cells available for ingestion is high. |
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