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1H NMR studies on thioamides: Barriers to internal rotation |
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| Authors: | J A Lepoivre H O Desseyn F C Alderweireldt |
| Abstract: | The barrier to the internal rotation of the dimethylamino group in thioamides of structure R? CS? N(CH3)2, R being (CH3)2,N? CS? , CH3O2C? or N?C? , is studied by proton magnetic resonance, using the lineshape analysis method of Nakagawa. In the solvents o-dichlorobenzene, naphthalene and nitrobenzene all ΔG≠ values are in the range of 23 to 24 kcal/mol. In these solvents the Ea and ΔS≠ values of each product are linearly related to the dielectric constants. |
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