Selective transformation of ascomycin into 11-epi-ascomycin |
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| Authors: | Karl Baumann Markus Bacher Annelaure Damont Andrea Steck |
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| Institution: | Department of Medicinal Chemistry, NOVARTIS Research Institute Vienna, Brunner Strasse 59, A-1235 Vienna, Austria |
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| Abstract: | Within the binding domain, ascomycin features the unusual pattern of a masked tricarbonyl moiety, which potentially allows for high structural diversity via simple isomerisation events. A cascade of diastereoselective rearrangement reactions at the binding domain, allowing the conversion of ascomycin into 11-epi-ascomycin is herein reported. |
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| Keywords: | Ascomycin Epimerisation Rearrangement Binding domain Tricarbonyl |
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