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Toward a synthesis of the antitumor macrolide peloruside A: a chiral pool approach for the C(1)-C(11) segment |
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| Authors: | Mukund K Gurjar Yakambram Pedduri CV Ramana Vedavati G Puranik Rajesh G Gonnade |
| Institution: | National Chemical Laboratory, Pune 411 008, India |
| Abstract: | Dihydroxylation of the glucose derived α,β-unsaturated lactones 6 and 13 was found to be on the α-face of the pyranolactone ring exclusively. The resulting dihydroxylated compound from 13 has been used in a synthesis of the lactone 4, which corresponds to C(1)-C(11) of peloruside A. |
| Keywords: | Barbies reaction Ring closing metathesis Dihydroxylation Barton-McCombie deoxygenation Mitsunobu reaction Dess-Martin periodinane |
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