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Synthesis of calix[4]arene library substituted with peptides at the upper rim |
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| Authors: | Hideaki Hioki Yumiko Ohnishi Miwa Kubo Emi Nashimoto Yukinori Kinoshita Miho Samejima Mitsuaki Kodama |
| Affiliation: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan |
| Abstract: | A fluorescence-labeled calix[4]arene library substituted with peptides at the upper rim was synthesized. Screening of the library for binding a dye-labeled oligopeptide indicated that some peptidocalix[4]arenes selectively bind the oligopeptide. The chemosensitivity of the library members for a target peptide was also investigated. |
| Keywords: | Calixarenes Combinatorial library Binding assay Chemosensors |
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