Basic alumina catalysed synthesis of substituted 2-amino-2-chromenes via three-component reaction |
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| Authors: | Raimondo Maggi Roberto Ballini Raffaella Sartorio |
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| Institution: | a ‘Clean Synthetic Methodologies Group’, Dipartimento di Chimica Organica e Industriale dell’Università, Parco Area delle Scienze 17A, I-43100 Parma, Italy
b Dipartimento di Scienze Chimiche dell’Università, Via S. Agostino 1, I-62032 Camerino (MC), Italy |
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| Abstract: | Substituted 2-amino-2-chromenes were obtained in excellent yield and selectivity simply by mixing malononitrile, α-naphthol and aromatic aldehydes in water in the presence of basic alumina as heterogeneous and reusable catalyst. |
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