Studies on uracils: a facile one-pot synthesis of oxazino[4,5-d]-, pyrano[2,3-d]-, pyrido[2,3-d]- and pyrimido[4,5-d]pyrimidines using microwave irradiation in the solid state |
| |
Authors: | Ipsita Devi |
| |
Affiliation: | Medicinal Chemistry Division, Regional Research Laboratory, Jorhat 785006, Assam, India |
| |
Abstract: | N,N-Dimethyl-5-formylbarbituric acid 1 reacts with maleimide 2 and phenyl isocyanate/phenyl isothiocyanate 4 under microwave-assisted conditions in the solid phase to afford pyrano[2,3-d]pyrimidines 3 and oxazino[4,5-d]pyrimidines 5 in excellent yields. Under identical conditions, N,N-dimethyl-6-amino-5-formyluracil 6 reacts with 2 and 4 to give pyrido[2,3-d]pyrimidine derivative 7 and pyrimido[4,5-d]pyrimidines 8 in high yields. |
| |
Keywords: | Microwave-assisted reaction Solid phase reaction Oxazino[4,5-d]pyrimidine Pyrido[2,3-d]pyrimidine Pyrimido[4,5-d]pyrimidine Pyrano[2,3-d]pyrimidine |
本文献已被 ScienceDirect 等数据库收录! |
|