Solid-phase approach towards the synthesis of functionalized imidazo[1,2-b]pyrazol-2-ones |
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| Authors: | Benjamin E. Blass Anil Srivastava Amy L. Faulkner James M. Ridgeway |
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| Affiliation: | a Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
b ChemBiotek Research International, Salt Lake, Block BN, Sector V, Kolkata 700091, India |
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| Abstract: | The solid-phase synthesis of a series of imidazo[1,2-b]pyrazol-2-ones, an interesting 5,5-fused ring system, based on diverse set of hydrazine acids and malanonitriles is described. The method involves formation of 5-aminopyrazoles on solid support and subsequent cyclizative cleavage off the resin. Compounds were obtained in acceptable to excellent yields and are suitable for biological evaluation without further purification. |
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