Shinsonefuran, a cytotoxic furanosesterterpene with a novel carbon skeleton, from the deep-sea sponge Stoeba extensa |
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| Authors: | Preecha Phuwapraisirisan Shigeki Matsunaga Nobuhiro Fusetani |
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| Affiliation: | a Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
b Institute for Systematics and Ecology, University of Amsterdam, PO Box 94766, 1090 GT Amsterdam, The Netherlands |
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| Abstract: | Shinsonefuran, a cytotoxic sesterterpene with a novel carbon skeleton, was isolated from the deep-sea sponge Stoeba extensa. The gross structure and relative stereochemistry of shinsonefuran were determined by spectral and chemical methods. In addition, relative stereochemistry of halisulfate 7, previously reported from a marine sponge Coscinoderma sp., was revised. Shinsonefuran exhibited cytotoxicity against HeLa cells with an IC50 value of 16 μg/mL. |
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| Keywords: | Deep-sea sponge Stoeba extensa Shinsonefuran Sesterterpenes Cytotoxic |
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