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Huge (14-, 21-, 28-, 35-, 56- and 70-membered ring) macrocyclic lactams--a novel family of carbopeptoid-cyclodextrins |
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| Authors: | Benjamin A Mayes David J Watkin George WJ Fleet |
| Institution: | a Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QY, UK b Chemical Crystallography Laboratory, Oxford University, 9 Parks Road, Oxford OX1 3QU, UK c Smith and Nephew Research Centre, York Science Park, York YO10 5DF, UK |
| Abstract: | Hydrogenation of linear ω-azido-pentafluorophenyl esters gives cyclic peptides containing 14-, 21-, 28-, 35-, 56- and 70-membered ring lactams from oligomers derived from ε-amino acids in excellent to moderate yields with a lack of racemisation during the cyclisation step. |
| Keywords: | cyclic peptide cyclodextrin sugar amino acid macrocyclic lactam biopolymer |
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