Palladium mediated stereospecific synthesis of 3-enynyl substituted thioflavones/flavones |
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Authors: | Manojit Pal |
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Affiliation: | Chemistry-Discovery Research, Dr. Reddy’s Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, India |
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Abstract: | The stereocontrolled synthesis of enynes has been accomplished via a sequential Heck-Sonogashira reaction in a simple synthetic operation. A variety of terminal alkynes were reacted with 3-iodo(thio)flavone in the presence of a palladium catalyst and a copper salt affording a mild and one-pot method for the first synthesis of the corresponding 3-enynyl and/or alkynyl derivatives. The mechanism and scope of the reaction are discussed. |
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Keywords: | 3-Enynyl/alkynyl thioflavones Stereocontrolled synthesis Palladium catalyst 3-Iodo(thio)flavone |
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