The preparation of a stable 2-pyridylboronate and its reactivity in the Suzuki-Miyaura cross-coupling reaction |
| |
| Authors: | Paul B. Hodgson Fabrice H. Salingue |
| |
| Affiliation: | Chemical Research and Development Department, Pfizer Global Research and Development, Pfizer Ltd, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK |
| |
| Abstract: | The preparation and reactivity of a 2-pyridylboronate stabilised by N-phenyldiethanolamine is described. In Suzuki-Miyaura cross-coupling reactions employing this boronate, significant aryl-aryl exchange from the phosphine ligand was observed with some combinations of ligand and substrates. The amount of the exchange by-product can be minimised by appropriate choice of phosphine ligand. |
| |
| Keywords: | 2-Pyridylboronate N-Phenyldiethanolamine Suzuki-Miyaura cross-coupling Tris(o-tolyl)phosphine Palladium(II)acetate |
| 本文献已被 ScienceDirect 等数据库收录！ |
