Synthesis of cyclic and acyclic Nα-methyl-Nω-alkyl-l-arginine analogues |
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| Authors: | Kyle P Kokko Thomas A Dix |
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| Institution: | a Department of Pharmaceutical Sciences, The Medical University of South Carolina, 280 Calhoun Street, Box 250140, Charleston, SC 29425, USA
b Argolyn Biosciences Inc., 710 Johnnie Dodds Blvd., Suite 202, Mt. Pleasant, SC 29464, USA |
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| Abstract: | A series of Nα-methyl-alkyl-l-arginine (Arg) analogues have been synthesized from inexpensive, commercially available starting materials. These analogues, once incorporated into pharmaceutically relevant peptides, are expected to increase binding affinity, receptor selectivity, lipophilicity, and stability as demonstrated with analogues of similar design and structure. |
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| Keywords: | Amino acids Arginine Peptides |
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