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Antiplasmodial cembradiene diterpenoids from a Southwestern Caribbean gorgonian octocoral of the genus Eunicea |
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| Authors: | Xiaomei Wei Peter Baran Juan A Sánchez José González |
| Institution: | a Department of Chemistry, University of Puerto Rico, PO Box 23346, UPR Station, San Juan 00931-3346, Puerto Rico b Department of Systematic Biology and Laboratories of Analytical Biology, Smithsonian Institution, PO Box 37012, Washington, DC 20013-7012, USA c Instituto de Investigaciones Científicas Avanzadas y Servicios de Alta Tecnología, Centro de Estudios Biomédicos, Clayton, Building 175, PO Box 7250, Panama 5, Republic of Panama |
| Abstract: | Five new representatives of the cembrane class of marine natural products have been isolated as minor metabolites from an undescribed species of Eunicea, a sea whip collected near the Colombian Southwestern Caribbean Sea. The structure of the crystalline metabolite 1 was solved by single-crystal X-ray diffraction analysis. Structures could then be proposed for cembradienes 2-5 by comprehensive spectral analyses involving 2D NMR, IR, UV, and high-resolution mass spectrometry, as well as chemical interconversion studies. Compound 1 exhibited weak cytotoxicity in the NCI 3-cell line panel human cancer screening program, whereas compounds 1, 2 and 4 displayed significant antiplasmodial activity against Plasmodium falciparum. |
| Keywords: | Diterpene Eunicea sp Single-crystal X-ray analysis Cytotoxicity Antimalarial Caribbean gorgonian octocoral |
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