Tandem amine propargylation-Sonogashira reactions: new three-component coupling leading to functionalized substituted propargylic amines |
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| Authors: | Nathanaë l Olivi,Jean-Daniel Brion |
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| Affiliation: | Laboratoire de Chimie Thérapeutique, BioCIS-CNRS (UMR 8076), Université Paris Sud, Faculté de Pharmacie, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France |
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| Abstract: | Three-component coupling reactions of propargyl halides, amines, and organic halides in the presence of palladium-copper catalysis produced efficiently highly functionalized propargylic amines in good to excellent yields at room temperature. Extension to the synthesis of 2-(dialkylaminomethyl)benzo[b]furan or indole derivatives is described. |
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| Keywords: | Sonogashira Propargyl halides Propargylic amines Palladium 2-(Dialkylaminomethyl)indoles 2-(Dialkylaminomethyl)benzofuranes |
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