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Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support |
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| Authors: | Akira Mori Issei Akahoshi Takayuki Doi |
| Affiliation: | a Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan b Graduate School of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan c Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo 152-8552, Japan |
| Abstract: | A liquid crystalline library of 100 molecules with three benzene rings and 18 molecules with two benzene rings was synthesized on solid support by means of benzoylation or acylation and palladium(0)-catalyzed carbonylation of a secondary amine obtained by a reductive amination of 4-iodoaniline and a backbone amide linker. The conversion and purity of the final products are high enough to investigate the mesomorphic properties. |
| Keywords: | Benzenoid liquid crystals Solid-phase synthesis Pd-catalyzed carbonylation |
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