A rapid and convenient synthesis of novel 1-imino-2,3-dihydro-1H-pyrazino[2,1,-b]quinazolin-5-ones |
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| Authors: | Maria de Fatima Pereira |
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| Affiliation: | Laboratoire de Biotechnologie et Chimie Bioorganique, CNRS FRE-2766, UFR Sciences Fondamentales et Sciences pour l'Ingénieur, Bâtiment Marie Curie, Université de la Rochelle, F-17042 La Rochelle cedex 1, France |
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| Abstract: | Exploring original approaches for the synthesis of therapeutic agents having a quinazoline part, we discovered that novel 3,4-dihydro-2H-pyrazino[2,1,-b]quinazolines (3) may be rapidly and easily obtained via the chemistry of 4,5-dichloro-1,2,3-dithiazolium chloride (1). Our synthetic approach of this reaction is described with the aim of obtaining a well-controlled access to this very rarely described pyrazino[2,1,-b]quinazoline skeleton. |
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| Keywords: | Quinazolin-4-ones 4,5-dichloro-1,2,3-dithiazolium chloride Pyrazino[2,1,-b]quinazolines Imidazo[2,1,-b]quinazolin-5-ones Anthranilate derivatives |
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