Enantioselective total synthesis of (+)-panepophenanthrin, a novel inhibitor of the ubiquitin-activating enzyme |
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Authors: | Goverdhan Mehta Senaiar S. Ramesh |
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Affiliation: | Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India |
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Abstract: | An enantioselective total synthesis of the novel natural product (+)-panepophenanthrin has been accomplished in which a biomimetic Diels-Alder dimerisation is a key step. The monomeric precursor 2 was assembled from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone through a short, simple sequence employing chemo- and stereoselective operations. |
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