(3R,4S)-3,4,5-Trihydroxy-4-methylpentylphosphonic acid, an isosteric phosphonate analogue of 2-C-methyl-d-erythritol 4-phosphate, a key intermediate in the new pathway for isoprenoid biosynthesis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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(3R,4S)-3,4,5-Trihydroxy-4-methylpentylphosphonic acid, an isosteric phosphonate analogue of 2-C-methyl-d-erythritol 4-phosphate, a key intermediate in the new pathway for isoprenoid biosynthesis

Authors:	Guillaume Hirsch

Institution:	CNRS UMR 7123, Institut Le Bel, Université Louis Pasteur, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France

Abstract:	2-C-Methyl-d-erythritol 4-phosphate (MEP) is the first intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis presenting the branched C₅ isoprene skeleton. Enantiopure (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid (MEP_N), an isosteric phosphonate analogue of MEP was synthesized from 1,2-O-isopropylidene-α-d-xylofuranose.

Keywords:	Biosynthesis Isoprenoids d-erythritol 4-phosphate" target="_blank">2-C-Methyl-d-erythritol 4-phosphate Phosphonate d-xylulose reducto-isomerase" target="_blank">1-Deoxy-d-xylulose reducto-isomerase d-erythritol 4-phosphate cytidyltransferase" target="_blank">2-C-Methyl-d-erythritol 4-phosphate cytidyltransferase
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