An improved synthesis of the scyphostatin side-chain |
| |
| Authors: | Graeme D. McAllister |
| |
| Affiliation: | Department of Chemistry, University of York, Heslington, York YO10 5DD, UK |
| |
| Abstract: | A formal synthesis of the lipophilic side-chain of scyphostatin has been achieved using a convergent synthesis, in 16% yield over six steps. This synthesis involves enzymatic desymmetrisation of a meso-diol, resolution of 2-methylbutan-1-ol, stereoselective hydrozirconation of a volatile acetylene and a Negishi-style cross coupling. |
| |
| Keywords: | Natural products Stereoselective synthesis Enzymes Desymmetrisation Cross-coupling |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
