Microwave assisted solvent free amination of halo-(pyridine or pyrimidine) without transition metal catalyst |
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| Authors: | Sanjay Narayan Robert E Gawley |
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| Institution: | Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA |
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| Abstract: | A solvent free direct amination of halo-(pyridine or pyrimidine) has been developed in good to high yields under computer-controlled microwave irradiation without transition metal catalyst. This reaction is a solvent and metal free, useful method for coupling of halo-(pyridine or pyrimidine) with pyrrolidine and piperidine derivatives by nucleophilic aromatic substitution (SNAr). |
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| Keywords: | SNAr Microwave Amination Halopyridine N-(Pyridyl)piperidine N-(Pyridyl)pyrrolidine |
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