A facile synthesis of benzo[c]phenanthridine alkaloids: oxynitidine and oxysanguinarine using lithiated toluamide-benzonitrile cycloaddition |
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Authors: | Thanh Nguyen Le |
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Institution: | College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Yong-Bong dong, Buk-gu, Kwangju 500-757, South Korea |
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Abstract: | Benzoc]phenanthridine alkaloids oxynitidine and oxysanguinarine were synthesized from easily available starting benzonitrile 5 and toluamide 6 using toluamide-benzonitrile cycloaddition reaction in six steps. This method is so highly efficient that it could be a more useful way for preparing fully aromatized benzoc]phenanthridine compounds. |
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Keywords: | Benzo[c]phenanthridine alkaloids Nitidine Sanguinarine Synthesis of natural alkaloids |
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