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Relationship between the structure and enantioselectivity in the asymmetric reduction of 2,6-disubstituted acetophenones with DIP-Chloride. An ab initio study |
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| Authors: | PVeeraraghavan Ramachandran Baoqing Gong Herbert C Brown Joseph S Francisco |
| Institution: | Herbert C. Brown Center for Borane Research, 560 Oval Drive, Department of Chemistry, Purdue University, West Lafayette, IN 47907-2084, USA |
| Abstract: | Using computational and chemical studies, a relationship between the % ee achieved and the dihedral angles between the plane of the aromatic ring and the plane containing the carbonyl group has been established for asymmetric reductions with B-chlorodiisopinocampheylborane. |
| Keywords: | Asymmetric reduction B-Chlorodiisopinocampheylborane Aralkyl ketones Dihedral angles |
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