Recent developments in the synthesis of 11β-aryl-estrone derivatives |
| |
| Authors: | Denis Prat,Franç oise Benedetti,Lahlou Nait Bouda,Gilles Franc Girard |
| |
| Affiliation: | Aventis Pharma, Chemical/Process Development, 102, route de Noisy, 93235 Romainville Cedex, France |
| |
| Abstract: | An industrial synthesis of 11β-aryl-estrone derivatives is described, based on the 1,4-addition of the aryl side-chain, as a cuprate, on to a mixture of allylic 5(10) alpha and beta epoxides, followed by hydrolysis and subsequent aromatization. |
| |
| Keywords: | Estrone derivatives Industrial synthesis Aromatization 11-β-Aryl estrogen |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
