Dynamic kinetic resolution (DKR) using immobilized amine nucleophiles |
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| Authors: | Yevgeny Valenrod |
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| Affiliation: | Department of Chemistry, University of Ottawa, Ottawa, ON, Canada K1N 6N5 |
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| Abstract: | The first example of a dynamic kinetic resolution (DKR) using immobilized amine nucleophiles is described. This approach utilizes a nucleophilic amine attached to a solid phase resin via an organic spacer. The optical purities of the N-substituted α-amino ester products are superior to the solution phase DKR with diastereomeric ratios ranging from 11:1 to 18:1 and chemical yields between 66% and 98%. |
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| Keywords: | Solid phase Dynamic kinetic resolution Resin-bound amine Immobilized amine |
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