Total synthesis of (+)-xyloketal D, a secondary metabolite from the mangrove fungus Xylaria sp. |
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| Authors: | Karsten Krohn Muhammad Riaz |
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| Institution: | Department of Chemistry, University of Paderborn, Warburger Straße 100, 33098 Paderborn, Germany |
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| Abstract: | (+)-Xyloketal D was prepared in a one-pot multistep domino reaction by heating optically active 5-hydroxy-4-methyl-3-methylenepentan-2-one (R) in toluene with 2,4-dihydroxyacetophenone. The absolute configuration of the natural product was confirmed by preparation of the starting enone from a lactone of established absolute configuration. |
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| Keywords: | Xyloketal D Total synthesis Ketal formation Marine secondary metabolites |
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