The synthesis of N-acyl-2-hydroxymethyl aziridines of biological interest |
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| Authors: | W Medjahed FZ Baba Ahmed H Merzouk |
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| Institution: | Laboratoire de Chimie Organique, Substances Naturelles et Analyses (COSNA), Faculté des Sciences, Université de Tlemcen, PO Box 119, 13000 Tlemcen, Algeria |
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| Abstract: | A practical synthesis of the title compounds from protected amino acylazides is described. All the compounds might be considered as a novel class of dipeptide isostere precursors; they all induce lymphocyte proliferation and protein production as observed from preliminary biological tests. |
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| Keywords: | Aziridines Peptide isosteres Amino acids |
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