Coupling reactions of aryl bromides with 1-alkynols catalysed by a tetraphosphine/palladium catalyst |
| |
Authors: | Marie Feuerstein Maurice Santelli |
| |
Institution: | Laboratoire de Synthèse Organique associé au CNRS, Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France |
| |
Abstract: | cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/PdCl(C3H5)]2 system catalyses efficiently the coupling reactions of aryl halides with a variety of alkynols such as propargyl alcohol, but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol. The catalyst can be used at low loading. Higher reaction rates were observed in the presence of but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol than with propargyl alcohol. The protection of the alcohol functions as an ether or a silyloxy group led generally to similar or better results than the reactions performed with the unprotected alcohols. |
| |
Keywords: | Palladium Catalysis Sonogashira reaction Alkynol Aryl bromide |
本文献已被 ScienceDirect 等数据库收录! |
|