Copper-catalyzed tandem reaction between imines and alcohols leading to indoles |
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| Authors: | Shin Kamijo Yoshinori Yamamoto |
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| Institution: | a Research Center for Sustainable Materials Engineering, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8578, Japan
b Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan |
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| Abstract: | A copper-catalyzed tandem reaction between 2-alkynyl-N-arylideneanilines and alcohols is found to produce N-(alkoxybenzyl)indoles in good to high yields. A wide variety of substituted N-(alkoxybenzyl)indole derivatives can be synthesized by utilizing this protocol, since the derived indoles are essentially formed by the four-component assemblies of aldehydes, 2-iodoanilines, terminal alkynes, and alcohols. |
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| Keywords: | indole copper catalyst imine alkyne alcohol |
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