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First synthesis of (±)-bis-homosarkomycin ethyl ester |
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| Authors: | Ali Samarat Hassen Amri |
| Institution: | a Laboratoire de Chimie Organique & Organométallique, Faculté des Sciences, Campus Universitaire, 2092 Tunis, Tunisia b Laboratoire de Chimie Organique & Organométallique, Université Bordeaux-1, 351 cours de la Libération, 33405 Talence Cedex, France |
| Abstract: | A five step synthesis of (±)-bis-homosarkomycin ethyl ester 6 has been achieved starting from commercially available ethyl phosphonoacetate and ethyl 5-bromovalerate. The successful synthetic approach to 6 uses α-methylene pimelate 3 as a key intermediate. |
| Keywords: | Horner-Wadsworth-Emmons reaction Functional phosphonoacetate Michael addition Cyclisation |
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