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Lipase-catalyzed enantioselective reaction of amines with carboxylic acids under reduced pressure in non-solvent system and in ionic liquids |
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| Authors: | Roxana Irimescu |
| Affiliation: | Bio-functional Ceramics Group, Ceramics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2266-98 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-8560, Japan |
| Abstract: | Lipase-catalyzed enantioselective acylation of 1-phenylethylamine and 2-phenyl-1-propylamine was performed by reacting the amines with carboxylic acids in a non-solvent system or in ionic liquids as reaction media. The reaction equilibrium was shifted toward amide synthesis by the removal of formed water under reduced pressure. |
| Keywords: | Enzymatic amide synthesis Ionic liquids Kinetic resolution Lipase Non-solvent reaction system Primary amine |
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