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Synthesis of a first thiophene containing analog of the HIV protease inhibitor nelfinavir |
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| Authors: | Carlo Bonini Lucia Chiummiento Margherita De Bonis Maria Funicello Paolo Lupattelli |
| Institution: | Dipartimento di Chimica, Università degli Studi della Basilicata, Via N. Sauro, 85, 85100 Potenza, Italy |
| Abstract: | A stereoselective and efficient preparation of a thiophene containing intermediate 2 from ethyl 3-thienyl propenoate 4 as the core of new possible HIV protease inhibitors is described. The chiral intermediate has been successfully used for the preparation of the analog 1 of the potent HIV inhibitor nelfinavir. |
| Keywords: | HIV-Pr inhibitors Peptidomimetics Hydroxyethylamine (HEA) inhibitors Nelfinavir analog Thiophene Sulfite |
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