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Rationalising the effect of reducing agent on the oxazaborolidine-mediated asymmetric reduction of N-substituted imines |
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| Authors: | Eirene H.M. Kirton Gary Tughan Russell E. Morris |
| Affiliation: | a School of Chemistry, University of St. Andrews, North Haugh, St. Andrews KY16 9ST, UK b School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK c GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG2 1NE, UK |
| Abstract: | Comparing the effect of borane-based reducing agents on the stereochemical outcome of oxazaborolidine-mediated ketone and N-substituted imine reduction highlights the potential importance of reducing agent structure on the asymmetric sense of imine reduction. |
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