Synthesis of Latia luciferin benzoate analogues and their bioluminescent activity |
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Authors: | Mitsuhiro Nakamura Mizuki Masaki Ryo Matsui Masashi Mamino Yoshihiro Ohmiya |
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Affiliation: | a Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan b The Special Division for Human Life Technology, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan |
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Abstract: | The bioluminescent system of the univalve shell Latia neritoides exhibits a luciferin-luciferase reaction. We study the enol formate structure of Latia luciferin, which is expected to be important for luminescent activity. The Latia luciferin analogues with an enol substituted benzoate moiety were synthesized and their bioluminescent activity was measured. The Latia luciferin benzoate analogues delay emission for natural luciferin in bioluminescence, indicating that the Latia bioluminescent activity can be controlled by the design of the enol ester. |
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Keywords: | Latia neritoides Luciferin Luciferase Bioluminescence Enol ester |
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