Daphniglaucin C, a novel tetracyclic alkaloid from Daphniphyllum glaucescens |
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| Authors: | Hiroshi Morita Ya-Ching Shen |
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| Institution: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
b Institute of Marine Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, ROC |
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| Abstract: | A novel Daphniphyllum alkaloid with an unprecedented tetracyclic ring system consisting of an octahydroindole and a hexahydroazulene rings, daphniglaucin C (1), has been isolated from the leaves of Daphniphyllum glaucescens and the structure and relative stereochemistry were elucidated on the basis of spectroscopic data. Daphniglaucin C (1) inhibited the polymerization of tubulin. |
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| Keywords: | Alkaloid Daphniphyllum glaucescens Daphniglaucin C NMR |
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