Facile syntheses of substituted 2,3-dihydrofurans and benzofurans by palladium-catalyzed reactions of propargylic carbonates with nucleophiles |
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| Authors: | Masahiro Yoshida |
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| Institution: | Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan |
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| Abstract: | Substituted 2,3-dihydrofurans and benzofurans are synthesized by the palladium-catalyzed reaction of 5-methoxycarbonyloxy-3-pentyn-1-ols and 1-(2-hydroxyphenyl)-3-methoxycarbonyloxy-1-propyne with nucleophiles, respectively. Various substituted propargylic carbonates and nucleophiles are efficiently transformed to their corresponding products. Additionally, a reaction using substrates containing a nucleophilic phenoxy group within the same molecule also produces the corresponding dihydrofuran. |
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| Keywords: | Palladium Cyclization Dihydrofurans Phenols |
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