Synthesis and structure of 5,5-diethoxycarbonyl-1-pyrroline N-oxide (DECPO). Application to superoxide radical trapping |
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| Authors: | Hakim Karoui Jean-Louis Clément Didier Siri |
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| Institution: | a Laboratoire SREP, UMR 6517 CNRS and Universités d’Aix-Marseille 1 et 3, Centre de Saint Jerome Case 521, Avenue Esc. Normandie Niemen, Marseille 13397, France
b Chemical Research Center, Institute for Chemistry, P.O. Box 17, H-125 Budapest, Hungary |
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| Abstract: | DECPO, a new analogue of EMPO was synthesized through a two-step synthetic pathway. Its structure and its application to trap superoxide were investigated. The ESR detection of the DECPO-OOH spin adduct is easy even at low concentration of superoxide. In comparison with DEPMPO, the trapping of superoxide with DECPO is faster and the detection of DECPO-OOH can be performed using a very low nitrone concentration (0.5 mM). |
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| Keywords: | nitrone spin trapping DECPO EMPO electron spin resonance superoxide |
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