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Chemoselective deprotection of acid labile primary hydroxyl protecting groups under CBr4-photoirradiation conditions |
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| Authors: | Ming-Yi Chen Laxmikant N. Patkar Adam Shih-Yuan Lee |
| Affiliation: | a Department of General Education, National Taipei College of Nursing, Taipei 112, Taiwan, ROC b Institute of Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC c Department of Chemistry, Tamkang University, Tamsui 251, Taiwan, ROC d Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300, Taiwan, ROC |
| Abstract: | The CBr4-photoirradiation in methanol generates a controlled source of HBr, which can chemoselectively deprotect commonly used hydroxyl-protecting groups in saccharides and nucleosides, such as tert-butyldimethylsilyl, isopropylidene, benzylidene and triphenyl ethers in the presence of other acid-labile functional groups. |
| Keywords: | CBr4-photoirradiation Deprotection |
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