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Diastereoselective alkylations of β-tetrazolyl propionic acids |
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| Authors: | Michael G Yang Dilip P Modi Ruth R Wexler Richard E Olson |
| Institution: | Bristol-Myers Squibb Company, Route 206 and Provinceline Road, Princeton, NJ 08540, USA |
| Abstract: | A new procedure for the diastereoselective alkylations of β-tetrazolyl propionic acids is described. A seven-membered chelation model is proposed to rationalize the observed high level of syn selectivity. |
| Keywords: | tetrazole diastereoselectivity alkylation chelation biol |
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