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Synthesis of an iminosugar based peptidomimetic analogue |
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| Authors: | Florence Chery |
| Affiliation: | Centre for Synthesis and Chemical Biology, Chemistry Department, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland |
| Abstract: | The synthesis of an 1-deoxymannojirimycin based analogue of a known HIV-protease inhibitor is described. The strategies employed for introduction of the pharmacophore groups onto the azasugar scaffold were based on regioselective reactions of the hydroxyl groups of the natural product and of d-fructopyranoside derivatives. |
| Keywords: | Peptidomimetic Scaffold Deoxynojirimycin Azasugar Deoxymannojirimycin Protease inhibitor |
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