Peptide synthesis on fluorous support |
| |
| Authors: | Mamoru Mizuno Kohtaro Goto Takeshi Matsuura |
| |
| Institution: | a The Noguchi Institute, School of Engineering, Tokai University, Japan
b Department of Applied Chemistry, School of Engineering, Tokai University, Japan |
| |
| Abstract: | New fluorous supports were synthesized and used to prepare a peptide having a C-terminal COOH based on fluorous chemistry. The hexakisfluorous chain-type support was suitable for the synthesis of a pentapeptide or a peptide derivative on a fluorous support whose fluorine content is over 40 w/w%. A bioactive peptide, Leu-enkephalin, was easily synthesized using an Fmoc-strategy based on fluorous chemistry. |
| |
| Keywords: | Fluorous support Leu-enkephalin Fluorous chemistry Peptide synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
