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Guaiacol transprotection: replacement of the phenoxy isopropyl protecting function by acetyl |
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| Authors: | Craig M Williams Lewis N Mander |
| Institution: | a Department of Chemistry, School of Molecular and Microbial Sciences, University of Queensland, St. Lucia, Brisbane 4072, QLD, Australia b Research School of Chemistry, Australian National University, Canberra 0200, ACT, Australia |
| Abstract: | A one-step method for the conversion of isopropyl protected guaiacols to the corresponding acetates is reported. Treating 6-substituted isopropyl protected guaiacols with trimethylsilyl trifluoromethanesulfonate in a mixture of acetic anhydride and acetonitrile affords 6-substituted guaiacol acetates in yields ranging from 35% to 99%. |
| Keywords: | Transprotection Isopropyl phenyl ether Trimethylsilyl trifluoromethanesulfonate |
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