Short asymmetric syntheses of homoallylic, homopropargylic and allenic silylated primary amines |
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Authors: | Sébastien Comesse |
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Institution: | Laboratoire de Synthèse Asymétrique (UMR 7611), Université P. et M. Curie, 4 place Jussieu, 75005 Paris, France |
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Abstract: | Amino alcohols derived from phenylglycinol and having vinyl-, alkynyl- or allenylsilane moieties were transformed in the corresponding primary amines in two steps: oxidative cleavage of phenylglycinol and transimination with phenylhydrazine. This methodology gave general access to enantiomerically enriched amines without loss of enantioselectivity. |
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Keywords: | β-Amino alcohols Phenylglycinol Silylated and unsaturated primary amines |
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