Dilactams. Synthesis of nonsymmetrical dibenzodiazocinediones |
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| Authors: | Alfred Hassner Bin Sun Simcha Meir |
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| Affiliation: | a Department of Chemistry, Bar-Ilan University, 52900 Ramat-Gan, Israel
b Compugen Ltd., Ashkelon, 78785 Haamal 11, Israel |
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| Abstract: | We report the first examples of nonsymmetrical dibenzodiazocinediones, mono-, di-, tri- and tetra-substituted in the aromatic rings including a benzo pyridino diazocine, by a new short method without the requirement of protection. The procedure involves conversion of an anthranilic acid to its sulfinamide lactone followed by direct heating with a different N-alkylanthranilic acid. |
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| Keywords: | Dilactam synthesis Eight-membered ring Diazocine Dibenzodiazocine Anthranilic acids |
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