Synthesis of a formamidine-protected 5-amino-2,5-dideoxyguanosine phosphoramidite and preparation of 5-acylamidooligonucleotides |
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| Authors: | Jan A Rojas Stütz |
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| Institution: | Institute for Organic Chemistry, University of Karlsruhe (TH), D-76131 Karlsruhe, Germany |
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| Abstract: | A 5′-amino-2′,5′-dideoxyguanosine phosphoramidite building block for DNA synthesis was prepared from 2-N-(dibutylformamidino)-2′-deoxyguanosine in four steps and 68% overall yield. Two of the three steps of the conversion from the 5′-alcohol to the monomethoxytritylamine were performed in the same flask. |
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| Keywords: | Aminonucleosides Oligodeoxyribonucleotides Phosphoramidites Mitsunobu reaction |
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