Stereoselective synthesis of (2R,3R) and (2R,3S)-3-hydroxyleucines |
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| Authors: | Sadagopan Raghavan KA Tony |
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| Institution: | Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A stereoselective synthesis of (2R,3R) and (2R,3S)-3-hydroxyleucine is disclosed. The key step of the reaction sequence involves, stereo- and regioselective bromohydration of 7, using a brominating agent derived in situ from N-bromosuccinimide and 2,6-lutidine, via intramolecular sulfinyl group participation. |
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| Keywords: | 3-Hydroxyleucine Intramolecular participation Bromohydration |
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