Synthesis of the tricyclic core structure of vindoline |
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Authors: | Zihong Guo |
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Affiliation: | Department of Chemistry, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA |
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Abstract: | An efficient synthesis of the core tricyclic structure (18) of vindoline has been achieved using the strategy, which features an intramolecular 1,3-dipolar cycloaddition of the azido dienone (12) to give aziridine (13) with complete region- and stereocontrol. |
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Keywords: | Vindoline Synthesis 1,3-Dipolar cycloaddition Birch reduction-alkylation |
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