Studies on the stability of the cyclobutane β-aminoacid skeleton: a cautionary tale |
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| Authors: | David J. Aitken Christine Gauzy Elisabeth Pereira |
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| Affiliation: | Laboratoire SEESIB-CNRS, Département de Chimie, Université Blaise Pascal--Clermont-Ferrand II, 24 Avenue des Landais, 63177 Aubière Cedex, France |
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| Abstract: | The 2-amino-1-cyclobutanecarboxylic acid skeleton undergoes facile retro-Mannich type ring opening in solution, which may lead to unexpected by-products during its synthesis or manipulation. |
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| Keywords: | β-Aminoacid Cyclobutane Retro-Mannich reaction |
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