The synthesis of indolo- and pyrrolo[2,1-a]isoquinolines |
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| Authors: | Charles B de Koning Joseph P Michael Rakhi Pathak Willem AL van Otterlo |
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| Institution: | Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, 2050 Johannesburg, South Africa |
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| Abstract: | The synthesis of fused isoquinolines from N-benzyl protected indoles and pyrroles is described. For example, treatment of t-butyl-2-(2-formyl-3,4-dihydro-1-naphthalenyl)-3-methyl-1H-indole-1-carboxylate with KOBut in DMF provided 14-methyl-8-phenylbenzoh]indolo2,1-a]isoquinoline in good yield. Analogous N-benzylpyrrole precursors could similarly be cyclized to give pyrrolo2,1-a]isoquinolines. |
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| Keywords: | Isoquinolines Potassium t-butoxide |
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