Novel and stereoselective asymmetric synthesis of an amino sugar analogue, furanodictine A |
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Authors: | Hidemi Yoda Yuji Suzuki Kunihiko Takabe |
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Affiliation: | Department of Molecular Science, Faculty of Engineering, Shizuoka University, Johoku 3-5-1, Hamamatsu 432-8561, Japan |
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Abstract: | A novel and efficient strategy is described for the asymmetric synthesis of the first 3,6-anhydrosugar to be isolated from natural sources, furanodictine A. The synthetic process is based on requisite stereodefined manipulation of the functionalized amino alcohol obtained through nucleophilic addition of vinyl Grignard reagent to the aminal incorporating the d-arabinofuranose-derived skeleton in a complete stereoselective manner. |
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Keywords: | Furanodictine 3,6-Anhydrosugar Amino alcohol Arabinofuranose |
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